Titlebook: Human Hemoglobin Genetics; George R. Honig,Junius G. Adams Book 1986 Springer-Verlag/Wien 1986 genetics

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The Genetics of the Human Globin Gene Loci: Formal Genetics and Gene Linkage,d their mutations are considered more systematically, both to define the specific principles of globin gene inheritance, and to formulate a rational basis for genetic counseling of families affected with these disorders.

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Introduction,f oxygen. An individual erythrocyte normally performs its work as a respiratory carrier for a period of three to four months, making a seemingly endless journey between the mainstream of its intravascular existence and the outreaches of the capillary tree. This efficiently functioning cell, and the

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The Human Globin Genes,etic information is stored in the form of deoxyribonucleic acid (DNA). Subsequent milestones in the advancement of knowledge of how DNA fulfills its role as a genetic carrier have included the elucidation of the helical structure of the DNA molecule and the complementary relationship of its base seq

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The Globin Gene Mutations,ar the most numerous of these mutations are those resulting from replacements of single nucleotide bases, and most of these mutant genes are expressed by the synthesis of structurally abnormal globin chains having substitutions of one of their amino acid residues. The substantial number of hemoglobi

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The Globin Gene Mutations, of clinical manifestations. The principal hematologic and clinical features of these conditions are considered briefly in the following sections, with emphasis on the mode of expression of their mutant genes. These disorders have been reviewed extensively in several recent texts (Lehmann and Huntsm

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The Geographic Distribution of Globin Gene Variation,ing been found in only one or a very limited number of individuals or families. Some of the other globin gene mutations have been shown to occur with relatively high frequency, but only in individuals within highly isolated populations. On the other hand, the group that includes Hb S, Hb C, Hb E, an