Titlebook: Human Experimentation; Methodologic issues Ton J. Cleophas Book 1999 Springer Science+Business Media Dordrecht 1999 assessment.clinical re

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Linear Scale Assessment of Relevant Domains of Quality of Life an example,.. High dosage nitrates were more effective for the management of anginal symptoms, but produced more adverse effects, including development of tolerance and the zero-hour effect (rebound angina at the end of the dosing interval). Such effects may reduce the beneficial effect of treatment on quality of life.

Kidnap

Informed Consent Under Scrutiny, Suggestions for Improvement,At the end of this centennial, as the 50th anniversary of the Nuremberg Code is commemorated, the consensus on individual autonomy and insistence on informed consent to research, that for the past 50 years has characterized bioethical thinking in human experimentation, is being scrutinized.

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Carryover Effects in Clinical Research,ous treatment. This, so called, carryover effect may bias any clinical trial in which subjects are tested more than once. Crossover studies can be routinely checked for this bias. In other study designs, however, common sense and alertness for unusual patterns in the data are the only defenses against it.

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朴素

Is Selective Reporting of Well-Designed Clinical Research Unethical as Well as Unscientific?, generally receive less interest from different parties including authors, editors and sponsors, and so, not-to publish such studies is a common phenomenon. Opinions differ on whether or not this phenomenon introduces imprecision into the assessment of health research and care.

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botany

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Delirium