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Titlebook: Hox Genes; Studies from the 20t Jean S. Deutsch Book 2010 The Editor(s) (if applicable) and The Author(s), under exclusive license to Sprin

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Control of Vertebrate Hox Clusters by Remote and Global ,-Acting Regulatory Sequencesrom those of the prototypic Drosophila Antennapedia (ANT-C) and Bithorax (BX-C) Complexes. If individual regulatory modules have been shown to recapitulate specific Hox expression patterns, other experimental studies underscore that vertebrate Hox clusters are controlled in many of their functions i
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Evolution of Hox Complexesempt to summarize these hypotheses, identify their strengths and weaknesses and highlight the types of new data that may lead to further resolution of the competing ideas. The major theme is that Hox genes originated very early in animal evolution and extensive independent duplications occurred in m
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Are the Deuterostome Posterior Hox Genes a Fast-Evolving Class?The posterior Hox genes have been of particular interest to both groups of biologists for a number of reasons: they appear to be associated with the evolution of a number of morphological novelties; the protostomes appear to be have lost a highly-conserved and functionally important amino acid motif
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Hox Genes and the Body Plans of Chelicerates and Pycnogonids classes of Hox genes can be distinguished, which are expressed in a typical staggered array along the anterior-posterior axis of the embryo in characteristically stable domains. These features have been used to align segments between different arthropod groups and in this way have contributed to so
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o major categories of genes including proto-oncogenes and suppressor genes, are affected. They can be distinguished according to positive or negative regulatory properties exerted on cell growth by their corresponding gene products. Genetic changes converting proto-oncogenes to oncogenes result in c
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