Titlebook: How to Overcome the Antibiotic Crisis; Facts, Challenges, T Marc Stadler,Petra Dersch Book 2016 The Editor(s) (if applicable) and The Autho

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New Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research mperative has not been met by the output of antibiotic research and development of the past decades for various reasons, including the declining efforts of large pharma companies in this area. Moreover, the majority of novel antibiotics are chemical derivatives of existing structures that represent

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Synthesis of Antibiotics,why these antibiotics were the ultimate synthetic targets in the past and how modern synthetic organic chemistry has evolved to address these challenges with new, improved strategies and methods. An additional aspect we would like to highlight here is the fact that these first syntheses had to be pa

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Antibiotics Clinical Development and Pipeline,inly small- and medium-sized biopharmaceutical companies to develop novel antibiotics up to market licensure, while major pharma players, with exceptions, have abandoned the space for a perceived lack of a return on their investment. The portfolio of approved drugs has improved over recent years for

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Emergence and Spread of Antimicrobial Resistance: Recent Insights from Bacterial Population Genomicrably evolving populations’. As a consequence, it was possible to reconstruct the emergence and spatial spread of drug-resistant bacteria on the basis of temporally structured samples of bacterial genome sequences. Based on currently available data, some general inferences can be drawn across different bacterial species as follows:

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978-3-319-84121-2The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl

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