Titlebook: How the Immune System Recognizes Self and Nonself; Immunoreceptors and Daisuke Kitamura (Professor) Book 2008 Springer-Verlag Tokyo 2008 V

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Fc Receptors,ptors link ancestral pathways of innate immunity to the specificity of the adaptive immune system. Their cellular expression pattern on myeloid effector cells, mast cells and B cells predicted their involvement in different types of inflammatory responses, allergy and B-cell regulation. Indeed, effe

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Self and Nonself Recognition by Coreceptors on B Lymphocytes: Regulation of B Lymphocytes by CD19, t mice, now it is clear that the regulations by these coreceptors physiologically play a significant role in the development, activation, proliferation and differentiation of B cells. Importantly, these coreceptors are able to detect and respond to extracellular environment and modulate BCR signalin

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Co-Receptors in the Positive and Negative Regulation of T-Cell Immunity, T-cell co-stimulator (ICOS) and cytotoxic T-cell antigen (CTLA-4), programmed death-1 (PD-1), B and T lymphocyte attenuator (BTLA) and T-cell immunoglobulin and mucin-domain-containing molecule- 3 (Tim-3). As will be outlined in this review, each of these receptors provides unique and overlapping s

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ect their lives from pathogens such as bacteria or viruses. The brain system may distinguish integrated images of self and nonself created from many inputs, such as vision, sound, smell, and others. The immune system recognizes and distinguishes a variety of structural features of self and nonself components.978-4-431-99831-0978-4-431-73884-8

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Recognition of Pathogens: Toll-Like Receptors,nize specific components of pathogens including bacteria, fungi, protozoa and viruses. Recognition of microbial components by TLRs triggers activation of signal transduction pathways, which then induces dendritic cell maturation and cytokine production, resulting in development of adaptive immunity.

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Self-nonself Recognition through B-Cell Antigen Receptor,ast, antigen receptors on B and T lymphocytes diversify enormously in each individual: genes for these receptors composed of multiple various parts are assembled randomly through gene recombination during development of these cells throughout the life of the individuals. While T-cell antigen recepto