Titlebook: How Free Cationic Polymer Chains Promote Gene Transfection; Yue Yanan Book 2013 Springer International Publishing Switzerland 2013 Cyclode

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Introduction and Background,d great interests over the past few decades. Advances in molecular biology and biotechnology as well as the completion of the Human Genome Project have led to the recognition of numerous diseases-relating genes. It has been gradually and generally realized that development of safe, efficient and con

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Revisiting Complexation Between DNA and Polyethylenimine: The Effect of Uncomplexed Chains Free in ical trials of viral carriers [1–3]. It has been well recognized that non-viral vectors have their own advantages, such as low immune toxicity, construction flexibility and facile fabrication, in the gene transfection, especially for clinical applications [4–6]. However, they are still much less eff

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Quantitative Comparison of Endocytosis and Intracellular Trafficking of DNA/Polymer Complexes in thpast few decades [1–3]. Particularly, cationic polymers are perceived as promising candidates due to their safety profiles and relative ease to incorporate desired functional moieties[4, 5]. Currently, polyethylenimine (PEI) is among the most intensively studied cationic polymeric vehicles and hithe

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