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Titlebook: Hormones in Human Amniotic Fluid; Adolf E. Schindler Book 1982 Springer-Verlag Berlin, Heidelberg 1982 Fruchtwasserdiagnostik.Hormones.Pro

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978-3-642-81658-1Springer-Verlag Berlin, Heidelberg 1982
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https://doi.org/10.1007/978-3-642-81656-7Fruchtwasserdiagnostik; Hormones; Proteohormon; Steroidhormon; protein hormones; steroids
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Steroid Conjugates in Human Amniotic Fluid,Besides the free moiety of the steroid molecule, biologically steroid hormones are to a large extent cojugated as sulfate or glucuronide as a monoconjugate or as a double conjugate, such as disulfate or mixed conjugate. Sulfates represent mainly a transport form and glucuronides are suitable for excretion.
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Fate of Steroids Injected into the Amniotic Cavity,The first report on dehydroepiandrosterone injection into the amniotic fluid of a patient with a live anencephalic fetus was made by Frandsen and Stakeman [279]. An increase of urinary estrogen excretion was noticed, particularly in the estrone-estradiol fraction. Similar findings were also obtained in women scheduled for legal abortion [107].
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Origin of Human Amniotic Fluid, the dorsal aspect of the germ disk [4, 5]. The amniotic sac enlarges rapidly and comes into contact with the internal surface of the chorion after the 2nd month of gestation [4]. As pregnancy progresses, the amnion differentiates into five distinct layers [6].
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Steroid Profiles in Human Amniotic Fluid and Distribution of Steroids in Several Compartments, found that they represent about 2 % of the total sterol content in human amniotic fluid and that about 10 %–20 % consist of cholestanol and cholesterol precursors [53]. The distribution of steroids (%) in various compartments and fetal substances is summarized in Table 71.
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