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Titlebook: Hormone Therapy in Breast and Prostate Cancer; V. Craig Jordan,Barrington J.A. Furr Book 2002 Springer Science+Business Media New York 200

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Clinical Utility of New Antiestrogenslowing tamoxifen failure. We have divided these new agents into three groups according to their target-site specificity and molecular properties .; tamoxifen-like agents, raloxifene-like agents, and pure antiestrogens.
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Pure Antiestrogensen. The term “pure” is used in the pharmacological sense, meaning an antagonist capable of complete blockade of the actions of the natural ligand (estradiol) and, as a corollory of this, being devoid of agonist (trophic) activity.
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Antiestrogens and the Cell Cycletomy in cases of pre-menopausal breast cancer could lead to tumor regression . Subsequent research in experimental models of carcinogeninduced mammary cancer revealed that estrogen was essential for both the initiation and progression of the disease. These observations, together with the demonstrati
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