| 书目名称 | Homocysteine Metabolism in Health and Disease | | 编辑 | Govind Prasad Dubey,Krishna Misra,Rudra P. Ojha | | 视频video | | | 概述 | Presents molecular, biochemical and pathophysiological implications of hyper-homocysteinemia.Discusses mechanisms associated with macro and micro-vascular disorders induced by hyper-homocysteinemia.En | | 图书封面 |  | | 描述 | This book comprehensively reviews the association of homocysteine metabolism with the etiology of various human disorders. The well-defined chapters embedded the central and peripheral effects of homocysteine metabolism intricately related with cardiovascular, neurodegenerative, metabolic, and autoimmune disorders. Further, it discusses the mechanisms of perturbance of cellular proteostasis by elevated homocysteine levels and provides a comprehensive account of pathophysiological consequences and clinical implications of homocysteine-containing proteins. The book also reviews association of genetic variants of homocysteine metabolic genes with type 2 diabetes mellitus and obesity. It also describes the molecular mechanism of hyperhomocysteinemia in the negative/feedback regulation of neural stem cell proliferation and alterations in DNA methylation. Taken together, it summarizes the mechanisms of hyper homocysteinemia-induced endothelial dysfunction and physiological functions of hydrogen sulfide as the protective agent.. | | 出版日期 | Book 2022 | | 关键词 | Homocysteine; Neurological disorders; Autoimmune disorders; Protein modification; Metabolic disorder | | 版次 | 1 | | doi | https://doi.org/10.1007/978-981-16-6867-8 | | isbn_softcover | 978-981-16-6869-2 | | isbn_ebook | 978-981-16-6867-8 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive licence to Springer Nature Singapor |
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发表于 2025-3-21 17:43:50
