Titlebook: Homocysteine; Related Vitamins and Christina Bolander-Gouaille,Teodoro Bottiglieri Book 2003Latest edition Springer-Verlag France 2003 Vita

背信

Why do Homocysteine Levels increase?,iseases and drugs can, directly or indirectly, disturb Hcy metabolism. Therefore, in most cases, elevated homocysteine levels are not caused by a single factor, but are the result of a cluster of factors, fig. 8.

overbearing

Clinical Impact of Enzyme Defects,ne β-synthase (CBS) gene, over 90 mutations have been identified so far. A few of these, often fairly common mutations, increase the enzyme activity, and thereby reduce tHcy levels. Others reduce the activity and may have a synergistic tHcy-increasing effect with, for instance, the C677T polymorphism.

AWE

Customary

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令人不快

Introduction,The importance of homocysteine as a risk factor or risk marker is becoming a familiar concept. Since the early 1990s a constantly increasing number of studies have been published on homocysteine. It has also been the topic of three international conferences, in 1995, 1998, and 2001.

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新义

Homocysteine Metabolism,Homocysteine is metabolised through two major pathways: transsulphuration and methylation. Normally, about 50% is re-methylated to form methionine, from which it originally derives.

Accolade

How can Homocysteine be Neurotoxic?,The proposed pathogenetic mechanisms, by which hyperhomocysteinemia may cause vascular damage, cognitive impairment, psychiatric and neurological complications, congenital defects, and pregnancy complications, converge.

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恶心

How to interpret the Test Results and how to handle Hyperhomocysteinemia?,Each laboratory uses a central 95% reference range based upon results from a general population. The reference limits are generally within the range of 5 and 13–15 µmol/L.