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派博传思国际中心 »期刊书目

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Titlebook: Histocompatibility Antigens; Structure and Functi P. Parham,J. Strominger Book 1982 Springer Science+Business Media Dordrecht 1982 Plantati

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书目名称Histocompatibility Antigens
副标题Structure and Functi
编辑P. Parham,J. Strominger
视频video
丛书名称World Crop Series
图书封面Titlebook: Histocompatibility Antigens; Structure and Functi P. Parham,J. Strominger Book 1982 Springer Science+Business Media Dordrecht 1982 Plantati
描述The Major Histocompatibility Complex (MHC) was discovered as a con­ sequence of the chronic problem encountered by cancer biologists in the early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. A number of observations pointed to genetic similarity being a prerequisite for successful transplantation and they were incorporated into a genetic theory of transplantation by C.C. Little. This prompted scientists like Little to initiate breeding experiments designed to test his hypothesis and produce genetically identical mice which would permit the growth of trans­ planted tumors. Most inbred strains of mice commonly used in immunology derive from those efforts. Transplantation of normal tissues obeyed the same rules found for malignant tissues and rejection was shown to be an immunological phenomenon. G.D. Snell showed that a single genetic locus determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this
出版日期Book 1982
关键词Plantation; Plasma; breeding; evolution; experiment; genes; growth; immune response; immunology; membrane; mou
版次1
doihttps://doi.org/10.1007/978-94-009-5894-4
isbn_softcover978-94-009-5896-8
isbn_ebook978-94-009-5894-4
copyrightSpringer Science+Business Media Dordrecht 1982
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书目名称Histocompatibility Antigens影响因子(影响力)




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MHC-Linked Complement Components,immunologic role has emerged — that of control of components of the complement system. Recognition of this function grew out of: 1. the definition of genetic variations in a specific mouse serum protein, the Ss (serum serological) trait, which became the primary genetic marker for the S region of th
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Evolution and Function of the Major Histocompatibility Complex,D in the mouse, D and A in the rat, A-B and C in the human, and so on. By this definition, any locus in this segment is part of the complex. However, such a definition is completely meaningless, because it makes no sense to partition a chromosome into arbitrary units consisting of loci that may be g
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978-94-009-5896-8Springer Science+Business Media Dordrecht 1982
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