Titlebook: Histochemical and Immunohistochemical Techniques; Applications to phar Peter H. Bach,John Baker Book 1991 Peter Bach and John Baker 1991 ce

Postulate

https://doi.org/10.1007/978-94-011-3094-3cell; pathology; tissue; toxicology

群岛

Why Use Histochemistry for a Better Understanding of Pharmacology and Toxicology?,Histochemistry is an image-based information-gathering strategy of particular value for biologists. To investigate biological substances, structures or processes using a histochemical method, a selective label is attached to the entity of interest. Such histochemical labels give rise to images visible in, or detectable by, a microscope.

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Image Analysis, Fluorescence and Laser Microscopy,he past decades however, developments such as fluorescently labelled monoclonal antibodies and hybridocytochemistry have increased the demands on microscope methods and thereby stimulated instrumentation research. For instance, when the fluorescence signal is very weak, a high contrast in the fluorescence image is demanded.

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ETCH

Whole-Body Autoradiography of Pharmaceuticals and Chemicals, during preparation. For this reason, it is common to perform studies using frozen specimens to obtain sections by cryomicrotomy. This chapter covers the study of xenobiotics in the body of animals, namely whole-body autoradiography.

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Immunochemical Methods to Assess Cellular Malfunction,ental animals and extrapolating the relevance of these data to risk assessment in man and for veterinary medicine. These reactions are usually seen as changes in cell or tissue function or as changes in structure (Glaister, 1986), but increased understanding is being derived from the applications of sub-cellular techniques.

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Inferior

Fixation of Tissue for Histochemistry,poned. Sometimes, however, because various techniques have to be used on a single small piece of tissue, a compromise will have to be reached. Wisdom without hindsight is often only a blessing of the gods!

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Pollutant-Induced Toxicity in the Marine Environment,o widely spread that they must now be regarded as constituents of natural systems in many instances (Goldberg ., 1978). Such contaminants include many metals, polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs).