Titlebook: Histamine and Histamine Receptors in Health and Disease; Yuichi Hattori,Roland Seifert Book 2017 Springer International Publishing AG 2017

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Histamine Clearance Through Polyspecific Transporters in the Brain,ely. The three transporters are expressed in the brain, and their regional distribution is different. Recent studies revealed the contribution of OCT3 and PMAT to histamine transport by primary human astrocytes. Several investigations using mice supported the importance of OCT3 for histamine clearan

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Histidine Decarboxylase Knockout Mice as a Model of the Pathophysiology of Tourette Syndrome and ReA) and has confirmed the etiologic, face, and predictive validity of the model. The .-KO model thus serves as a unique platform to probe the pathophysiology of TS and related conditions, and to generate specific hypotheses for subsequent testing in humans. This chapter summarizes the development and

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Histamine Food Poisoning,ize the occurrence of histamine. Further studies are necessary to estimate the human exposure and the relationship between the total amount of the biogenic amines ingested with food and health effects.

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Role of the Histamine H3 Receptor in the Central Nervous System, against the wake-promoting, anticonvulsant and anorectic effect of histamine (via postsynaptic H. receptors) and its procognitive activity (via postsynaptic H. and H. receptors). Indeed, H. agonists and H. inverse agonists elicit essentially the same effects, at least in rodents; these effects are

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Clinical Development of Histamine H4 Receptor Antagonists,wed anti-inflammatory and anti-pruritic activity preclinically. JNJ 39758979 advanced into human clinical studies and showed efficacy in reducing experimental pruritus and in patients with atopic dermatitis. However, development of this compound was terminated due to the occurrence of drug-induced a

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Histamine and Histamine Receptors in Allergic Dermatitis,ls, and induces scratching behavior in CACD. The administration of H1 or H4 receptor antagonists was effective to ameliorate these symptoms in murine CACD models. The combination of H1 and H4 receptor antagonists is a potential therapeutic target for chronic inflammatory skin diseases such as CACD a

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