Titlebook: Histamine and Histamine Receptors in Health and Disease; Yuichi Hattori,Roland Seifert Book 2017 Springer International Publishing AG 2017

混合,搀杂

Yuichi Hattori,Roland SeifertAuthors will cover hot topics in the field..Update on last HEP volume on histamine published 25 years ago..Unique topics are combined a in novel way.Includes supplementary material: .Includes suppleme

Processes

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Eructation

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Structural Analysis of the Histamine H1 Receptor,ihistamine. The crystal structure showed that doxepin sits deeply inside the ligand-binding pocket and predominantly interacts with residues highly conserved among other aminergic receptors. This binding mode is considered to result in the low selectivity of the first-generation antihistamines for H

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Molecular Modelling Approaches for the Analysis of Histamine Receptors and Their Interaction with Lrent types of assays or mutagenesis studies. To obtain insights into the histamine receptors on a molecular and structural level, crystal structures have to be determined and molecular modelling studies have to be performed. It is widely accepted to generate homology models of the receptor of intere

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Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutants in thels, and the use of different species orthologues render it difficult to compare and interpret the published results. Thus, the four human histamine receptor subtypes were analyzed side-by-side in the Sf9 insect cell expression system, using radioligand binding assays as well as functional readouts p

FANG

Histamine Release from Mast Cells and Basophils,other amines (e.g., serotonin), proteases, proteoglycans, cytokines/chemokines, and angiogenic factors and rapidly released upon triggering with a variety of stimuli. Moreover, mast cell and basophil histamine release is regulated by several activating and inhibitory receptors. The engagement of dif

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内疚

Histamine H1 Receptor Gene Expression and Drug Action of Antihistamines,d. Levels of histamine H. receptor mRNA and IL-4 mRNA in nasal mucosa were elevated by the provocation of nasal hypersensitivity model rats. Pretreatment with antihistamines suppressed the elevation of mRNA levels. Scores of nasal symptoms were correlatively alleviated to the suppression level of mR

Regurgitation

Histamine Clearance Through Polyspecific Transporters in the Brain,nergic neuronal activity. Histamine .-methyltransferase, which is an enzyme in the central nervous system that metabolizes histamine, is localized to the cytosol. This suggests that a histamine transport process is essential to inactivate histamine. Previous reports have shown the importance of astr