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Titlebook: Histamine II and Anti-Histaminics; Chemistry, Metabolis Mauricio Rocha e Silva Book 1978 Springer-Verlag Berlin Heidelberg 1978 Antihistami

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发表于 2025-3-21 16:47:15 | 显示全部楼层 |阅读模式
书目名称Histamine II and Anti-Histaminics
副标题Chemistry, Metabolis
编辑Mauricio Rocha e Silva
视频video
丛书名称Handbook of Experimental Pharmacology
图书封面Titlebook: Histamine II and Anti-Histaminics; Chemistry, Metabolis Mauricio Rocha e Silva Book 1978 Springer-Verlag Berlin Heidelberg 1978 Antihistami
描述In the preface to Part I of this volume, which appeared in 1966, we stated: " ... we had to leave the Antihistaminics for another volume of unpredictable dimensions. In 1924, eight pages inserted in a Chapter on Mutterkorn by Arthur R.Cushing were considered enough, in Vol. II, Part II, pp. 1319-1326 of the Hand­ buch. Now 922 pages did not suffice to cover all aspects of the subject ... the subject has been expanded in so many directions, that the anti histaminic part had to be excluded from the present volume. Possibly, another thousand pages will be necessary to cover what remains of the subject."* This prediction was fulfilled, and the subject of histamine has grown to such an extent that dealing with the antihistaminics only in Part II would be quite inadequate. It is imperative to include the large number of recent findings on the subject of histamine, namely the splitting of its pharmacologic receptors, and the great variety of new contributions on ,its participation in physiopathologic phenomena, metabolism and interaction with newly found mediators.
出版日期Book 1978
关键词Antihistaminikum; Histamin; chemistry; metabolism; research
版次1
doihttps://doi.org/10.1007/978-3-642-66445-8
isbn_softcover978-3-642-66447-2
isbn_ebook978-3-642-66445-8Series ISSN 0171-2004 Series E-ISSN 1865-0325
issn_series 0171-2004
copyrightSpringer-Verlag Berlin Heidelberg 1978
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Absorption, Distribution, Metabolism, and Elimination of Antihistaminesss, such investigations are instructive and serve to provide a base line for future more sophisticated experimental design using radiolabeled materials. Readers of this chapter are cautioned to evaluate carefully the significance and interpretation of metabolic studies which do not make use of radiolabeled drugs.
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Pharmacological Actionsc amine exerts on the systemic, cardiac and regional vasculatures, including those on the microcirculation and vascular smooth muscle. Moreover, species differences among mammals with respect to some of these actions have not been critically evaluated in the past.
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Metabolism and Excretion of Histaminedecarboxylase has been detected in all tissues of commonly studied species, and in tested tissues of other species. From the distribution and inducible characteristics of histidine decarboxylase, physiologic roles for histamine have been proposed in microcirculatory control, some cases of rapid growth, and as a neurotransmitter in brain.
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Book 1978ble dimensions. In 1924, eight pages inserted in a Chapter on Mutterkorn by Arthur R.Cushing were considered enough, in Vol. II, Part II, pp. 1319-1326 of the Hand­ buch. Now 922 pages did not suffice to cover all aspects of the subject ... the subject has been expanded in so many directions, that t
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Kinetics of Antagonist Actionamine. In the present subchapter we will study general aspects of that interaction, having in view the possibility of developing a general theory that might embody the interaction of agonists (including cholinomimetics) and antagonists with receptors, from a thermodynamic standpoint.
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