Titlebook: Hirschsprung’s Disease and the Allied Disorders; Status Quo and Futur Tomoaki Taguchi,Hiroshi Matsufuji,Satoshi Ieiri Book 2019 Springer Na

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,Genetic Aspect of Hirschsprung’s Disease,e of the enteric neural crest-derived cells (ENCCs), which give rise to the enteric nervous system (ENS), to migrate, proliferate, differentiate or survive in the bowel wall. This results in clinically severe and sometimes life-threatening bowel obstruction. Developmental biologists and human geneti

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,Sacral Pathway Theory of Hirschsprung’s Disease,ial direction with most of the aganglionic segment occurring in the hindgut area and no abnormality being present in the pelvic nervous system. Several hypotheses of the cause of HSCR exist. Huther et al. speculated that the lesion was due to abnormalities in the lumbosacral nerves where the ganglio

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Classification,the world yet. Generally, it is classified as “short-segment aganglionosis” when the aganglionic segment extends to the sigmoid colon; especially, the aganglionic segment extends only to the rectum under peritoneal reflection, which is termed as “rectal aganglionosis” (Fig. 8.1a), and extends to the

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Enterocolitis,-associated enterocolitis vary from mild to severe, and it sometimes becomes a serious and life-threatening condition. Historically, surgical procedures for Hirschsprung’s disease have significantly progressed, but Hirschsprung’s disease-associated enterocolitis remains a frequent complication befor