Titlebook: Hippocampal Microcircuits; A Computational Mode Vassilis Cutsuridis,Bruce Graham,Imre Vida Book 20101st edition Springer-Verlag New York 20

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Book 20101st editionis an unparalleled resource of data and methodology that will be invaluable to anyone wishing to develop computational models of the microcircuits of the hippocampus. The editors have divided the material into two thematic areas. Covering the subject’s experimental background, leading neuroscientist

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Synaptic Plasticity at Hippocampal Synapses This includes the contribution of presynaptic and postsynaptic spiking and the importance of subthreshold postsynaptic depolarisation. Also, this chapter will attempt to relate various induction protocols to known in vivo patterns of neuronal activity.

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Neuronal Activity Patterns in Anaesthetized Animalstputs and discharge pattern of anatomically defined single cells and to correlate these activities with a detailed knowledge of how the cells are incorporated into the surrounding hippocampal network, the coordinated activity of other cells in that network and ultimately the resultant behavioural consequences.

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Spatial and Behavioral Correlates of Hippocampal Neuronal Activity: A Primer for Computational Analys it sometimes seems there are as many behavioral correlates as experimental paradigms in which they might be observed. The challenge is not to find correlates of neural activity in the hippocampus – it is to make sense of the broad range of sensory- and behavior-related firing properties observed.

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Microcircuit Model of the Dentate Gyrus in Epilepsye and components is important for developing therapeutic interventions for treating neurological disorders such as epilepsy. Epilepsy and the process by which a normal brain becomes epileptic (epileptogenesis) are complex themselves, however, and result in myriad changes to the dentate gyrus on both molecular and cellular levels.

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Single Neuron Models: Interneuronsar that plasticity (Perez et al. 2001) and place cell coding (Maurer et al. 2006; Wilent and Nitz 2007) specifically involve interneurons and that interneurons are specific targets of neuromodulation (Glickfeld and Scanziani 2006; Lawrence et al. 2006b).

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Physiological Properties of Hippocampal Neuronse type and timing of neuronal responses to synaptic inputs depend on the firing pattern of each neuron, which in turn is set by the interplay of intrinsic and synaptic electrophysiological properties.