Titlebook: High Pressure Bioscience; Basic Concepts, Appl Kazuyuki Akasaka,Hitoshi Matsuki Book 2015 Springer Science+Business Media Dordrecht 2015 Fu

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This chapter presents an introduction to the book. It starts with on overview of the value and limits the use of informetric indicators in research assessment, and presents a short history of the field. It continues with the book’s main assumptions, scope and structure. Finally, it clarifies the terminology used in the book.

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978-94-024-0225-4Springer Science+Business Media Dordrecht 2015

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High Pressure Bioscience978-94-017-9918-8Series ISSN 0306-0225 Series E-ISSN 2542-8810

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Early Days of Pressure Denaturation Studies of Proteins0 atm within 30 min by Bridgman (J Biol Chem 19:511–512, 1914), and Kiyama and Yanagimoto (Rev Phys Chem Jpn 21:41–43, 1951) confirmed that the coagulation occurs above 3,880 kg cm.. Grant et al. (Science 94:616, 1941) and Suzuki and Kitamura (Abstracts of 30th annual meeting of Japanese Biochemical

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Protein Denaturation on ,-, Axes – Thermodynamics and Analysisrrect function, study of their structural changes attracted great interest in the past decades. The three dimensional structure of proteins is influenced by several factors including temperature, pH, presence of chaotropic and cosmotropic agents, or presence of denaturants. Although pressure is an e

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预知

Why and How Does Pressure Unfold Proteins?14). Since that time a large and recently increasing number of studies of pressure effects on protein stability have been published, yet the mechanism for the action of pressure on proteins remains subject to considerable debate. This review will present an overview from this author’s perspective of

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Pressure-Dependent Conformation and Fluctuation in Folded Protein Moleculesthe range of fluctuations at ambient pressure. The largest changes are around cavities and buried water molecules. Sheets distort much more than helices. Hydrogen bonds compress about 0.012 Å kbar., although there is a wide range, including some hydrogen bonds that lengthen. In the presence of ligan

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