Titlebook: High Density Digital Recording; K. H. J. Buschow,Gary J. Long,Fernande Grandjean Book 1993 Springer Science+Business Media Dordrecht 1993

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few decades, though, our ability to control the disease in tropical countries has been unimpressive. The widespread emergence of drug-resistant malarial parasite strains, combined with repeated failure to develop inexpensive, reliable, lasting immunization strategies, has resulted in a global health

Culmination

Employee

J. M. Fedeliesearch, not to mention sporadic studies undertaken by other research workers and organisations. While most people engaged in the search for new drugs agree that a rational approach based on knowledge of the intimate biochemical pathways of the target cells would be ideal as well as intellectually s

Outwit

先行

ANIM

皱痕

S. B. Luitjens the most part, considered only those drugs or compounds that have shown an activity sufficient to focus broad attention upon them. Because established drugs are discussed elsewhere in this volume (see Chap. 1), much of the discussion in this chapter will centre on research and development efforts t

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J. C. Lodder liver forms of . and . (. 1980). The clinical use of PQ as a causal prophylactic and therapeutic agent is, however, curtailed by its toxic side effects, especially for those patients having glucose-6-phosphate dehydrogenase-deficient erythrocytes (. et al. 1962). Much research has, therefore, been

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R. W. Chantrell,K. O’gradyfor clinical use. The possible value of drug combinations in the prevention of drug resistance will be covered in Chap. 16. Combinations of drugs may be considered under several headings, namely those that are complementary (e.g. against different stages of a parasite), combinations that are additiv

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