Titlebook: Hi-C Data Analysis; Methods and Protocol Silvio Bicciato,Francesco Ferrari Book 2022 Springer Science+Business Media, LLC, part of Springer

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n should be the number-one concern. If anterior knee pain after ACL reconstruction does occur, the symptoms can usually be alleviated through nonoperative means. Occasionally, surgical intervention may become necessary. Other causes for this pain syndrome are rare but with proper evaluation can easily be differentiated and treated.

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钢笔尖

Analysis of Hi-C Data for Discovery of Structural Variations in Cancer, confounding factors. SVs change the spatial distance of genomic regions and cause discontinuous signals in Hi-C, which are difficult to analyze by routine informatics practice. Here we provide step-by-step guidance for how to identify SVs using Hi-C data and how to reconstruct Hi-C maps in the presence of SVs.

微生物

Metagenomes Binning Using Proximity-Ligation Data,omosome conformation capture experiments (3C, Hi-C), also known as proximity-ligation approaches, applied to metagenomics samples. Here, we present a simple computational pipeline that allows to recover high-quality Metagenomics Assemble Genomes (MAGs) starting from metagenomic 3C or Hi-C datasets and a metagenome assembly.

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A Polymer Physics Model to Dissect Genome Organization in Healthy and Pathological Phenotypes,l and computational approaches, based on polymer physics, can be employed to dissect chromatin contacts in three-dimensional space and to predict the effects of pathogenic structural variants on the genome architecture. In particular, we discuss the folding of the human . and the murine . loci as case studies.

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Antecedent

Polymer Modeling of 3D Epigenome Folding: Application to Drosophila,on the spatial genome organization. Here, I describe how polymer-based models can be practically used to study the role of epigenome in chromosome folding. I illustrate this methodology in the context of . epigenome folding.

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Book 2022i-C to address a variety of biological problems, with a specific focus on state-of-the-art computational procedures adopted for the data analysis. Written in the highly successful .Methods in Molecular Biology .series format, chapters include introductions to their respective topics, lists of the ne