Titlebook: Hepatocytes; Methods and Protocol Patrick Maurel Book 2010 Humana Press 2010 Cryopreservation.Detoxication.Drug/xenobiotic metabolism and t

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The Use of Human Hepatocytes to Investigate Drug Metabolism and CYP Enzyme Induction, Major problems were linked to poor metabolic stability and drug–drug interactions linked to inhibition or induction of metabolism. Since most small molecule (MW below 1000) drugs are cleared from the body by the liver, primary cultures of human hepatocytes became the most predictive and widely used

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Metabonomic Studies on Human Hepatocyte in Primary Culture,etry-based metabonomics as a global investigation tool. Sample preparation to data analysis have been detailed in an approach enabling to separate drug-induced (endogenous metabolites) and drug-related (drug metabolites) biomarkers for reference inducers. Rifampicin, a nuclear pregnane X receptor (P

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