| 书目名称 | Hepatobiliary and Pancreatic Carcinogenesis in the Hamster | | 编辑 | Yoshitsugu Tajima,Tamotsu Kuroki,Takashi Kanematsu | | 视频video | | | 概述 | Includes supplementary material: | | 图书封面 |  | | 描述 | Malignant neoplasms occurring in the biliary tract and pancreas remain a therap- tic challenge. The mechanism of carcinogenesis as well as the growth and spread of these tumors is still poorly understood, making the development of rational tre- ment strategies difficult. In order to improve the clinical results achieved by sur- cal or other medical treatment of such malignant tumors, the establishment of an experimental animal model is critical. For this purpose, attempts were made to induce carcinoma experimentally in the biliary tree and finally an animal model using the hamster was established in 1994 at our laboratory. Because the tumor in this model mimicked the characteristics of human tumors, a series of experimental investigations were conducted to clarify the pathological characteristics of biliary carcinoma, the genetic alterations during biliary carcinogenesis, and the relationship between biliary inflammation and c- cinogenesis. The chemopreventive effects on the occurrence of biliary carcinoma were also successfully examined. In addition, in vitro studies led to the establi- ment of transplantable biliary cancer cell lines and biliary epithelial cell lines by utilizing | | 出版日期 | Book 2009 | | 关键词 | Biliary Carcinoma; Chemoprevention; Experimental Carcinogenesis; Hamster; Pancreas; Pancreatic Carcinoma; | | 版次 | 1 | | doi | https://doi.org/10.1007/978-4-431-87773-8 | | isbn_softcover | 978-4-431-99859-4 | | isbn_ebook | 978-4-431-87773-8 | | copyright | Springer-Verlag Tokyo 2009 |
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发表于 2025-3-21 19:06:20
