| 书目名称 | Heparanase | | 副标题 | From Basic Research | | 编辑 | Israel Vlodavsky,Ralph D. Sanderson,Neta Ilan | | 视频video | | | 概述 | Features a comprehensive and detailed discussion of the biology of heparanase and heparanase-2 and its role and function in aggressive cancer phenotypes.The book‘s 8 chapters are written by internatio | | 丛书名称 | Advances in Experimental Medicine and Biology | | 图书封面 |  | | 描述 | .Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. .Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therap | | 出版日期 | Book 2020 | | 关键词 | heparanase; carcinoma; sarcoma; cell microenvironment; metastasis; angiogenesis; hematological malignancie | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-34521-1 | | isbn_softcover | 978-3-030-34523-5 | | isbn_ebook | 978-3-030-34521-1Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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发表于 2025-3-21 20:05:43
