Titlebook: Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist; Valerie I. Brown Book 2018 Springer International Publi

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HSCT Recipient Pretransplantation Evaluationf latent infections, all HSCT candidates undergo a thorough infection evaluation . to the start of the conditioning regimen. All potential HSCT recipients also undergo restaging or reassessment of their disease state. The results of this evaluation along with the results of the other pre-HSCT testin

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How to Select a Donor and Hematopoietic Stem Cell Source: Related Versus Unrelated Donors for Allogevaluating histocompatibility is termed HLA matching and can be performed at the antigen and allele level. The allele level is more accurate and thus is termed “high-resolution” typing. Because increased HLA disparity between the donor and recipient increases post-HSCT morbidity and mortality, every

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Preparing the Patient for HSCT: Conditioning Regimens and Their Scientific Rationaleies almost completely on significant immunosuppression to permit the host’s immune system to allow the donor HSCs to reside in HSC bone marrow niches and repopulate the host’s immune system with the donor’s. This chapter discusses the rationale for the need of conditioning; the types of conditioning

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Engraftment Syndrome and Associated Cytokine Storm and Capillary Leak Syndromethy. CLS is characterized by weight gain, generalized edema, hypotension, prerenal failure, ascites, intravascular depletion, and pericardial and/or pleural effusions. CLS typically first manifests 1–3 days . to neutrophil recovery as measured by a detectable ANC in the blood, whereas ES typically o

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Mucositis and Pain in the Peri-HSCT Period this chapter focuses on opioid options and discusses the principles of conversion between opioids, use of caregiver-/patient-controlled analgesia (which can facilitate better pain control and result in a lower total amount of opioids needed), management of opioid side effects, and guidelines for we

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Hepatotoxicity in the Peri-HSCT Periodad, and infection/sepsis. The most common hepatic complications during the peri-HSCT period are transaminitis, sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD), acute graft versus host disease (GvHD) of the liver, and infections involving the liver. Because infections and acute GvHD