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Titlebook: Hematologic Challenges in the Critically Ill; Aryeh Shander,Howard L. Corwin Book 2018 Springer International Publishing AG, part of Sprin

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Hematologic Challenges in ICU Patients with Malignancy,den. Oncogenes activate blood coagulation as an integral feature of neoplastic transformation whereby cancer cells support clot formation and clotting proteins support cancer growth and dissemination. A complex coagulopathy develops characterized by activation of clotting mechanisms to different ext
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Current Risks of Transfusion,al risks. Over time, the risks associated with transfusion have become increasingly well understood. However, most clinicians think only of transfusion-transmitted infections such as hepatitis B and C and human immunodeficiency virus in regard to transfusion risk. There are many other transfusion ri
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Clinical Outcomes and Red Blood Cell Storage, blood cell transfusions (Shehata et al. Transfusion 54:2631-9, 2014; Vincent, JAMA 288:1499-507, 2002; Corwin, Crit Care Med 32:39-52, 2004). Our understanding of the biochemical, structural, and functional changes that occurs to red blood cells with storage – also known as the storage lesion – has
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Therapeutic Apheresis for Hematologic Emergencies,s, most often discarding one (red cells, plasma, white cells, or platelets); and returned to the patient with or without extracorporeal modification or a replacement fluid. Multiple TA modalities can be used in the intensive care setting including therapeutic plasma exchange, red blood cell exchange
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Intravenous Oxygen Therapeutics: A Revolution in Medicine Yet to Be Realized?,has pursued an oxygen therapeutic since the early 1930s with actually some spotty points of success. There are places in the world today that such agents are available, but they have not realized their potential. Two distinctly different pharmaceutical approaches are under accelerated development: h
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