Titlebook: Heat Shock Proteins: Potent Mediators of Inflammation and Immunity; Alexzander A. A. Asea,Antonio De Maio Book 2007 Springer Science+Busin

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HSP-APC Interactions: Initiation of Immune Responsesurs through surface receptors on the APC such as CD91. Other molecules such as CD40, LOX-1, CD36, Toll-like receptor-2 & 4, SR-A and SREC-I have also been proposed to be HSP receptors and are discussed. The physiological situations where the HSP-APC interaction is necessary such as cross-priming of

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Extracellular Functions for an Intracellular Protein: GRP94/GP96 Interactions with the Mammalian Imm tumor progression. Extending from early studies into the identity(s) of tumor-specific antigens, the landmark discovery of an immunogenic function for GRP94/gp96 prompted the hypothesis that GRP94/gp96 functions as a cross-presentation antigen and, by virtue of a peptide binding activity, bears the

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Hsp-Induced Stimulation of Immune Responses class I. Maturation of DC is stimulated by HSP, upregulating the costimulatory molecules CD40, CD80 and CD86, as well as MHC class II, all of which enhance immune responses. The state of maturity of DC may be significant in the balance between immunity and tolerance. Innate immunity is elicited by

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The Role of Heat Shock Proteins in the Elicitation of Immune Responsesresponses. The exact manner in which they do so, their physiological role in this process, and their distinct ability to promote adaptive immune response is the subject of this chapter. The first part of the chapter will deal with the general known antigenic stimulation properties of heat shock prot

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Hsp70 Family Members, Danger Signals and Autoimmunitynditions. Hsp70 proteins are present in pathogens as well as in healthy cells. They can be expressed constitutively or elevated in response to heat or other cellular stress. Immune responses stimulated by Hsp70 family members include triggering of innate inflammatory responses, enhancing antigen pre

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HSP60: A Pleiotropic Immune Signal B cells were observed in almost all inflammatory diseases. Moreover, HSP60 induces pro-inflammatory phenotype in innate immune cells via Toll-like receptors (TLRs). Accordingly, HSP60 has been considered a pro-inflammatory “danger signal”. However, HSP60 have immunoregulatory potential and could ar

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