Titlebook: Heat Shock Protein 60 in Human Diseases and Disorders; Alexzander A. A. Asea,Punit Kaur Book 2019 Springer Nature Switzerland AG 2019 Chap

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HSP60 as Modulators of Apoptosis important functions in cells during normal conditions. Majority of heat shock proteins execute the role of molecular chaperones by enabling the unfolded protein to fold properly. Heat shock protein 60 (HSP 60) plays a significant role in protein homeostasis inside the mitochondria. Aberrant express

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Role of the Post-translational Modifications of HSP60 in Diseaseher pro- and anti-apoptotis and signalling functions which it achieves through a variety of post-translational modifications (PTMs). Increasing evidence indicates that in disease states from cancer to systemic inflammation, such modifications become dysregulated, and as a result HSP60 cannot perform

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Hsp60 in Cancer Immunity: Biological Basis, Diagnostic Potential and Therapeutic Opportunities, Hsp60 participates in disease progression through its involvement in immunoescape. In this chapter, the interactions between Hsp60 and the tumor microenvironment are discussed as they offer key elements to illustrate the context-dependent functions of Hsp60 in tumor immunomodulation. Next, the app

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Hsp60 Involvement During Carcinogenesiscts with various molecules that are responsible of apoptosis, cell proliferation and other mechanisms involved when a normal cell becomes malignant. Hsp60 expression was found to be increased in many types of cancer but in same tumors of different anatomical district was found decreased. The mechani

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Anti-human Hsp60 Autoantibodies in Autoimmune and Inflammatory Rheumatic Diseases(AIRDs), including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis, Sjogren’s syndrome and various idiopathic vasculitides. Anti-human Hsp60 autoantibodies can be detected in the sera of patients with AIRDs in various frequencies and levels; therefore, their diagnos

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Hsp60 in Atherosclerosis: Past, Present and Futures and the smooth muscle cell layer of vessels. T cells that recognize endogenous Hsp60 on endothelial cells initiate the disease. Here, we first describe the initial experiments that led to the discovery of Hsp60 as an autoantigenic driver of atherosclerosis. Then, we address numerous epidemiologica