Titlebook: Heart Failure in Adult Congenital Heart Disease; Lorna Swan,Alexandra A. Frogoudaki Book 2018 Springer International Publishing AG, part o

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Rafael Alonso-Gonzalez M.D., M.Sc. small motoneurones are recruited before larger ones. The intrinsic basis for this behaviour is given by the fact that an excitatory input system (for example the Ia fibres) evokes large EPSPs in small and small EPSPs in large α-motoneurones. It has been proposed that this is a universal feature of

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Lorna Swanunable to provide complete identification of both AAT alleles. Gene sequencing of complete . gene by using the Sanger method or next-generation sequencing (NGS) is crucial to enable correct diagnosis in patients with alpha1-antitrypsin deficiency caused by uncommon AAT variants..This protocol explai

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Despina Ntiloudi M.D.,George Giannakoulas M.D., Ph.D.ation advice from the experts.This volume provides a collection of protocols that will allow researchers to further explore the multiple, fascinating activities of  Alpha-1 Antitrypsin (AAT) isoforms in innate immunity, and gene therapy. Written in the highly successful .Methods in Molecular Biology

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tions are similar to human cells. Some therapeutics, such as mRNA vaccines, target nonnative cells that may contain inefficient secretory machinery. For example, gene replacement therapies for alpha-1 antitrypsin (AAT), a glycoprotein normally produced in hepatocytes, are often targeted to muscle ce

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