Titlebook: Handbuch Kindheits- und Jugendforschung; Heinz-Hermann Krüger,Cathleen Grunert,Katja Ludwig Living reference work 20200th edition Erziehu

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Jürgen Budde,Georg Rißler early transcription units 1 (E1) and 4 (E4). The strategy involves three recombinant plasmids containing E1 (pE1-1235), E4 (pE4-1155), or the wild-type genome that lacks a portion of E3 (pH5.4100). To generate recombinant viruses, mutations are first introduced into pE1- and/or pE4-transfer plasmid

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Heinz-Hermann Krüger,Cathleen Grunert,Katja Ludwigsgene expression (.,.). To detect the CTL response to adenovirus proteins or inserted transgenes in a mouse model, even with multiple in vivo immunizations, a secondary in vitro restimulation is necessary. The CTL response to adenovirus tends to focus on one or a few immunodominant epitopes. Using s

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Heinz-Hermann Krüger polypeptides (.–.), most of which have been detected in infected cells. Analysis of E4 mutants has implicated E4 products in a variety of processes that occur in infected cells, including viral early and late gene expression, DNA replication, the shutoff of host-cell protein synthesis, transformati

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美色花钱

Anne Schippling,Catharina I. Keßler(El) gene products are sufficient for complete transformation of rodent cells in vitro by these viruses. During the past quarter century, the processes by which E1A proteins, in cooperation with E1B proteins, perturb the cell cycle and induce the transformed phenotype, have become well defined. Some

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Merle Hummrich,Merle Hinrichsenrs offer many advantages for gene delivery: they are easy to propagate to high titers, they can infect most cell types regardless of their growth state, and in their most recent embodiments they can accommodate large DNA inserts. In this chapter, the development of adenovirus vectors is reviewed, fr

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Sabine Walper,Rudolf Tippelt the group C adenoviruses in vivo, but also fibers from other groups except group B in vitro. The latter viruses seem to utilize a different receptor. The receptor accumulates at, or close to, the tight junction in polarized epithelial cells and probably functions as a cell-cell adhesion molecule. T

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Cathleen Grunertles of normal and malignant cell growth. Much of this knowledge stems from analyses of their productive infection cycle in permissive host cells. Also, initial observations concerning the carcinogenic potential of human adenoviruses subsequently revealed decisive insights into the molecular mechanis

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