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Titlebook: Handbook of Neuroengineering; Nitish V. Thakor Reference work 2023 Springer Nature Singapore Pte Ltd. 2023 Brain structure and function.Vi

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Biomimetic Approaches Towards Device-Tissue Integrationomimetic approaches encompass methods that alter the biological environment through mechanical, topographical and biological approaches. This chapter examines recent developments in bioinspired soft and functional materials designed for neural interfaces and their application to neuroprosthetic devi
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State-of-the-Art Technology on MEAs for Interfacing Live Neuronsactivity of nerve cells in vitro. Based on the multichannel extracellular recording technique, MEAs can measure electrical signals such as extracellular spikes and local field potentials at the level of single cells from in vitro neural network models (e.g., dissociated cell culture, acute brain sli
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Challenges for Large-Scale Brain-Machine Interfacesreas of the brain. Cortical BCI technologies aimed at accessing these distributed computations are thus anticipated to require a large number of spatially diverse, implanted electronic listening posts or nodes, appropriately positioned in physical proximity to the sources of these neural signals. Fr
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High-Density Fiberless Optoelectrodes with Integrated Waveguides and μLEDses. Optogenetics provides the capability to excite or inhibit activities of specific neurons in intact animals with millisecond precision. This light-induced stimulation technique can be combined with electrophysiology to enable simultaneous control of target neurons and recording of the associated
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Nanostructured Platforms Interfacing with Nervous Systemwith the system and regulate dysfunctional neuronal circuits. Recent advances in nanotechnology enable the construction of nanostructured platforms with ultrasmall feature size and superior material property at the nanoscale, targeted at interfacing with the nervous system seamlessly. The chapter pr
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Regenerative Electrodes for Peripheral Nerve Interfacingeir geometry. Since the nerve is first severed prior to regeneration through a device, they constitute the most invasive type of interface – their use is predicated on the implant being placed near the ends of stumps formed following nerve transection. Since peripheral nerve fibers regenerate vigoro
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