Titlebook: Handbook of Drug Monitoring Methods; Therapeutics and Dru Amitava Dasgupta Book 2008 Humana Press 2008 Detailed mechanisms.False negative.F

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Digoxin, serum by using immunoassays. Endogenous compounds are termed as digoxin-like immunoreactive substances (DLIS) and elevated DLIS concentrations are encountered in volume-expanded patients such as those with uremia, essential hypertension, liver disease, and preeclampsia. DLIS cross-reacts with anti-

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Immunosuppressive Drugs,ions of immunosuppressive drugs. Therapeutic monitoring of cyclosporine, tacrolimus, and sirolimus is currently considered an integral part of organ transplant programs, and compelling arguments have been made for monitoring mycophenolic acid. Although high-performance liquid chromatography (HPLC) i

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Pharmacogenomics and Personalized Medicine,omics is concerned with the whole genome effect on drug metabolism and efficacy, pharmacogenetics is readily defined as the study of the genetic effect, for example, single-nucleotide polymorphism, on an individual’s ability to metabolize a drug or compound. Pharmacogenomic biomarkers, in combinatio

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Interference of Heterophilic and Other Antibodies in Measurement of Therapeutic Drugs by Immunoassaheterophilic antibody may arise in a patient in response to exposure to certain animals or animal products, or to infection by bacterial or viral agents, or non-specifically. Among the anti-animal antibodies, the most common occurrence is of human anti-mouse antibody because of the wide use of murin

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,Drug–Herb and Drug–Food Interactions, supplement, induces cytochrome P 450 mixed function oxidase as well as modulated P-glycoprotein in intestine and reduces plasma concentrations of cyclosporine, tacrolimus, amitriptyline, digoxin, fexofenadine, indinavir, methadone, midazolam, nevirapine, phenoprocoumon, squinavir, simvastatin, theo

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Toxic Element Testing with Clinical Specimens,th. Laboratory testing can help identify unrecognized exposures as well as monitor-associated decontamination efforts. Regular testing is also important to identify exposures in populations that are at high risk for exposure to a specific toxic element. For example, aluminum is important to monitor

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Alcohol Testing,d forensic laboratories. Although blood alcohol measurement is most commonly used, alcohol can also be measured in breath, urine, saliva and vitreous humor. Whole blood alcohol levels are lower than serum alcohol levels, and the value depends on the hematocrit. Although enzymatic assays based on cap