Titlebook: HPV Infection in Head and Neck Cancer; Wojciech Golusiński,C. René Leemans,Andreas Dietz Book 2017 Springer International Publishing Switz

北京人起源

, despite their generally advanced stage at presentation. In general, HNSCCs develop in precancerous mucosal changes, and the apparent lack of precancerous HPV+ve mucosal changes is therefore remarkable. In this Chapter, head and neck carcinogenesis is discussed and the molecular differences between HPV+ve and HPV-ve tumors are outlined.

RALES

昏睡中

反省

Confound

宏伟

HERTZ

拍下盗公款

Variation of HPV Subtypes with Focus on HPV-Infection and Cancer in the Head and Neck Regionn subtypes are essentially heterogeneous in efficacy triggering neoplastic transformation and cancer development. This could explain differences in the clinical course of HPV-driven head and neck cancer.

MOT

Systemic Treatment in HPV-Induced Recurrent or Metastatic HNSCCHPV in the R/M situation are still scarce. Due to the rising incidence of HPV-associated cancers, the number of R/M HPV+ carcinomas is also expected to rise. This chapter therefore aims to give an overview of the current knowledge concerning the role of HPV as a prognostic and predictive marker in recurrent or metastatic HNSCC.

察觉

Should We De-escalate the Treatment for HPV-Positive Tumors?clinical reports and lack of data of prospective trials not mature for routine clinical decision making in 2016. Independent of the currently lacking evidence for HPV-dependent treatment de-escalation, there are some relevant arguments to address this question in ongoing and future trials.