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Titlebook: HLA Class II Antigens; A Comprehensive Revi Bjarte G. Solheim (Director),Erna Møller,Soldano F Book 1986 Springer-Verlag Berlin Heidelberg

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书目名称HLA Class II Antigens
副标题A Comprehensive Revi
编辑Bjarte G. Solheim (Director),Erna Møller,Soldano F
视频video
图书封面Titlebook: HLA Class II Antigens; A Comprehensive Revi Bjarte G. Solheim (Director),Erna Møller,Soldano F Book 1986 Springer-Verlag Berlin Heidelberg
描述This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans­ plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in "immune surveillance" against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers.
出版日期Book 1986
关键词Histokompatibilität; T cell; antibody; antigen; diseases; genetics; hematopoiesis; histocompatibility; immun
版次1
doihttps://doi.org/10.1007/978-3-642-70367-6
isbn_softcover978-3-642-70369-0
isbn_ebook978-3-642-70367-6
copyrightSpringer-Verlag Berlin Heidelberg 1986
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https://doi.org/10.1007/978-3-319-04600-6ies were found directed against polymorphic determinants present on the surface of B cells. These alloantisera were able to block a mixed lymphocyte reaction (MLR) and defined an allelic system that correlated with the MLC-defined D antigens.
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The Complexity of HLA-DQ Moleculesies were found directed against polymorphic determinants present on the surface of B cells. These alloantisera were able to block a mixed lymphocyte reaction (MLR) and defined an allelic system that correlated with the MLC-defined D antigens.
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Structural and Functional Studies of Mouse Class II Genes encoded in the D region of the HLA complex. Class II molecules play an important role in the generation of immune responses because they are involved in the recognition of foreign antigens by regulatory T cells (for recent reviews see [28, 65]).
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Cross-reactions of Class II Histocompatibility Antigens of Various Speciesl structure and domain organization of the genes coding for class I and class II antigens of the MHC in various species. Biochemical characterization of the histocompatibility antigens has shown their basic molecular structure to be the same in every species so far examined.
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