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Titlebook: H-2 Antigens; Genes, Molecules, Fu Chella S. David Book 1987 Springer Science+Business Media New York 1987 antigen.antibodies

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Origins of , Polymorphisms in wild mouse populations, but we do know that the number is large as far as the functional loci [., and .] are concerned (Klein and Figueroa 1981, 1986). We have thus far extracted 71 ., 68 ., 66 .., and 53 .. alleles from wild mouse populations (Klein and Figueroa 1986, Bukara et al. 1985, Nizet
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The Relative Contributions of Gene Conversion-Like Substitutions and Unique Mutations Toward Polymor class I and class II loci mapping in the K, D, and I regions. This polymorphism has two components. The first is the large number of alleles identified in the wild (Klein and Figueroa, 1981). None of these alleles is present in the population at high frequencies and the total number of alleles is e
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Involvement of the , Complex in Steroid Hormone Metabolismgl II) and probed with human 21-OHase cDNA clone. Combined restriction fragment length polymorphism identify six different patterns of endonuclease fragment polymorphism of the murine . region. Furthermore, we have investigated the serum level of two steroid hormones (progesterone and corticosterone
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Some Recent Data on the Q-Subregion Genes and Their Productseries of class I molecules which are 80–90% homologous to the more classical . and . genes. Because of this homology, we have frequently hypothesized that these genes have an important function in the immune system. However, recent data showing large deletions in the Q subregion, without any overt e
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Toward an Understanding of the Biochemical Nature of H-2 Molecules: A Historical Perspectivel account of those studies from my laboratory which were carried out with the objective to understand the biochemical nature of H-2 molecules. This work was performed with the goal of relating the structural features of what are now called class I MHC molecules to their biological function, in addit
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The Analysis of H-2 Mutants: Molecular Genetics and Structure/Function Relationshipscontain the genes encoding the classical H-2 transplantation antigens (K, D, L). Alleles of each of the K, D and L loci exhibit substantial sequence diversity (1–3). Further, H-2 loci are highly polymorphic, with over 100 alleles identified per locus (3). The high sequence diversity and polymorphism
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