| 书目名称 | Fortschritte der Chemie Organischer Naturstoffe / Progress in the Chemistry of Organic Natural Produ | | 编辑 | G. Cimino,R. M. Coates,C. Toniolo,W. Herz,H. Grise | | 视频video | http://file.papertrans.cn/347/346439/346439.mp4 | | 丛书名称 | Fortschritte der Chemie organischer Naturstoffe‘ Progress in the Chemistry of Organic Natural Produc | | 图书封面 |  | | 出版日期 | Book 1976 | | 关键词 | Coenzym; Naturstoffe; Rearrangement; chemistry; natural product; natural products; protein; research | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-7091-3262-3 | | isbn_softcover | 978-3-7091-3264-7 | | isbn_ebook | 978-3-7091-3262-3Series ISSN 0071-7886 | | issn_series | 0071-7886 | | copyright | Springer-Verlag Wien 1976 |
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Front Matter |
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Abstract
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| 2 |
,Natural Products from Porifera, |
L. Minale,G. Cimino,S. De Stefano,G. Sodano |
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Abstract
Since organic chemistry began, the chemistry of natural products from terrestrial organisms such as plants and fungi has been studied intensively; in contrast, marine species have received relatively little attention. However, in the last decade research in the field of marine products has increased sbstantially. The heightened interest in this area is attested by the appearance of the monumental treatise of . on Poisonous and Venomous Marine Animals in 1965 (.), . review on “Marine Pharmacology” in 1969 (.) and . recent book “Chemistry of Marine Natural Products” (.) in 1973. In addition . review devoted to the Chemistry of Natural Products Derived from Marine Sources, was published in volume . of this series in 1971 (.).
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,Biogenetic-Type Rearrangements of Terpenes, |
Robert M. Coates |
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Abstract
A remarkable characteristic of naturally occurring terpenes is the bewildering array of carbocyclic structures. As of 1970 more than 200 different carbon skeletons had been identified (excluding nor metabolites), the structures varying from acyclic chains to hexacyclic ring systems and containing almost all ring sizes from three to fourteen members (.). Although a considerable number of the 200 are produced by oxidative transformations (.. .., ring cleavage) of pre-existing terpenes, a majority nevertheless represent primary structures formed in nature through multistep cyclization and rearrangement sequences originating from five basic acyclic precursors.
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,Chemistry of the Ansamycin Antibiotics, |
K. L. Rinehart Jr.,L. S. Shield |
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Abstract
The ansamycins constitute a class of antibiotics characterized by an aliphatic bridge linking two non-adjacent positions of an aromatic nucleus. The name, originally suggested by ., is derived from the term “ansa compounds” coined by . in 1942 (.). It is the structures of the ansamycins which have provided the name for these antibiotics and their structures are remarkably complex, as we shall see in the next section, but it is the bioactivities which have attracted the greatest attention. A derivative of one of the rifamycins, rifampicin, is marketed widely for treatment of tuberculosis and other infections caused by gram-positive organisms (.), while other derivatives of rifamycin and streptovaricin are biological probes because of their binding to DNA-dependent RNA polymerase (., ., .) and their inhibition of reverse transcriptases (., ., ., ., ., ., ., .). Maytansine and related compounds are powerful anti-tumor agents (., ., ., .). Bioactivities of the ansamycins have been reviewed extensively elsewhere (., ., ., ., ., .) and need not be exhaustively described here, although they will be noted in the section of this review dealing with reactions of individual antibiotics. Inste
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,The Chemistry of Tryptophan in Peptides and Proteins, |
A. Fontana,C. Toniolo |
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Abstract
The chemistry of tryptophan (.) has probably been the object of more intense investigation than that of any other amino acids. This is undoubtedly due to the particular reactivity of the indole nucleus and to the extensive chemistry developed over the years regarding this important and ubiquitous functionality. Only the sulfur amino acids have received comparable attention from chemists and biochemists.
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,The Present Status of Flavin and Flavocoenzyme Chemistry, |
P. Hemmerich |
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Abstract
The term “flavin” stands for the yellow redox-active subgroup of the first coenzyme ever to be elucidated in terms of molecular structure. The “heroic” period of redox-enzymology of the early thirties ended in .. (.–.) description of the first enzyme ever to be split reversibly to yield coenzyme and apoprotein. This was the NADPH-oxidizing “Old Yellow Enzyme” from yeast, whose biological function is still unknown even nowadays. The structure of the coenzyme has been shown to be riboflavin-5’-phosphate, viz. a phosphate derivative of vitamin B., which had been synthesized somewhat earlier by . group (.), who based this work upon even more important chemical precursor studies of . and coworkers (., .) and on the biochemical work of . and . (.).
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Back Matter |
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Abstract
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