| 书目名称 | Folyl and Antifolyl Polyglutamates |
| 编辑 | I. David Goldman,Bruce A. Chabner,Joseph R. Bertin |
| 视频video | |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | The role of folylpolyglutamates in biosynthetic processes has gained increasing importance with the recognition that these com pounds are not only the forms of folate co-factors that accumulate within cells, but, in addition, are the preferred substrates for folate dependent reactions in eukaryotic cells. More recently attention has turned to the potential importance of the polyglutamyl derivatives of methotrexate that have been detected in normal and malignant cells both in vitro and in vivo. The biochemical trans formation of this important chemotherapeutic agent is of particular significance since polyglutamyl derivatives of methotrexate are not only potent inhibitors of the target enzyme, but have quite different cellular pharmacokinetics than the parent monoglutamate. Hence, nearly three and a half decades after 4-aminoantifolates were first applied clinically in the treatment of human neoplasms, we have begun to appreciate a new dimension in antifolate pharmaco logy which may have profound implications for our understanding of the mechanism of the cytotoxicity and selectivity of this class of agents. With the development of highly sensitive methodology for the rapid detect |
| 出版日期 | Book 1983 |
| 关键词 | attention; cells; cognition; cytotoxicity; development; kinetics; methodology; pharmacokinetics; toxicity; tr |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4757-5241-0 |
| isbn_softcover | 978-1-4757-5243-4 |
| isbn_ebook | 978-1-4757-5241-0Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
发表于 2025-3-21 16:58:16
