Titlebook: Exploring Protein Structure: Principles and Practice; Tim Skern Textbook 2018 Springer International Publishing AG, part of Springer Natur

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https://doi.org/10.1007/978-981-15-3840-7and the β-sheet. In this chapter, the secondary structure elements themselves will be presented in more detail. First, we will learn how residues are assigned to such elements by different algorithms. This will reveal that the assignments of secondary structures are subject to some uncertainty and m

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https://doi.org/10.1007/978-981-16-7739-7t protein is p21., a molecule that binds guanosine diphosphate (GDP) in the ground state and guanosine triphosphate (GTP) in the activated state. It is of therapeutic interest because activation can be brought about by the hormone insulin; in addition, p21. is often mutated in human cancers. The sec

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Dynamical Behavior of Dislocations,in the structures of proteins composed mostly of β-sheets. One common arrangement of β-strands is called a β-sandwich because two sets of hydrogen-bonded strands pack back to back; the side-chains are the filling of the sandwich. As a classic example, we will examine the immunoglobulin fold and its

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Exploring Protein Structure: Principles and Practice

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2509-6125 from structural biology in their assignments and research and will be a valuable source of information for all those interested in applied and theoretical aspects of structural biology.. .978-3-319-76857-1978-3-319-76858-8Series ISSN 2509-6125 Series E-ISSN 2509-6133

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,Examining α-Helical Proteins,hree proteins have similar α-helical Bcl-2-like folds but perform different functions. One protein acts to prevent the onset of apoptosis (i.e., it is a pro-survival factor for a cell), whereas the second acts to induce the onset of apoptosis (i.e., it is a pro-apoptotic factor). The third, from vac

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https://doi.org/10.1007/978-981-16-7739-7 binding or exchanging ligands and visualize how the proteins form complexes with their specific macromolecular interaction partners. These investigations will illustrate basic principles from the previous four chapters and will provide you with the skills and tools required to compare structures by