Titlebook: Exploring the Vertebrate Central Cholinergic Nervous System; Alexander G. Karczmar (Professor and Chair Emeritu Book 2007 Springer-Verlag

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Water Science and Technology Libraryates, control of movement, thermoregulation, reward behaviors, and the generation of epileptic foci. This chapter provides an overview of current knowledge regarding the structure, function, and pharmacology of the mAChRs, with a particular emphasis on their roles in the CNS. For a historical introduction, see Chapter 4 A-E.

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Induction

https://doi.org/10.1007/978-3-7091-7037-3nesterases (antiChEs) (.; .; ., .; see .; .; and .; ., .; see also Chapter 8 A). Also, Henry Dale surmised early the presence of a ChE from his demonstration of the evanescence of the action of ACh (., .; see also Chapters 7A, 8A, and 9A).

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History of Research on Nicotinic and Muscarinic Cholinergic Receptors,nomic, and peripheral motor systems were laid down; in fact, even 250 years earlier the great da Vinci had rendered in his fi gures with much precision and few errors the details of the nervous systems (and other tissues).

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,Links Between Amyloid and Tau Biology in Alzheimer’s Disease and Their Cholinergic Aspects,ystem in view of the apparent preference of plaques, bundles, and degenerative proteins for the central cholinergic neurons. This matter and its consequences are discussed in section 2 of this introduction and expanded upon in section K (.).

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em, neuropharmacology, and the associated neurological diseaEven if the “weapons of mass destruction” (WMD) and, among them, stocks of organoph- phorus (OP) agents (also referred to as war gases and nerve gases) were not found in Iraq following the US-Iraq war, the relative ease with which these sub

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