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Titlebook: Experimental Design and Reproducibility in Preclinical Animal Studies ; José M. Sánchez Morgado,Aurora Brønstad Book 2021 Springer Nature

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书目名称Experimental Design and Reproducibility in Preclinical Animal Studies
编辑José M. Sánchez Morgado,Aurora Brønstad
视频video
概述Comprehensive guide on how to design and conduct reproducible animal studies.Introduction to statistical methods essential for performing animal studies.Discusses in detail how factors like genetic ba
丛书名称Laboratory Animal Science and Medicine
图书封面Titlebook: Experimental Design and Reproducibility in Preclinical Animal Studies	;  José M. Sánchez Morgado,Aurora Brønstad Book 2021 Springer Nature
描述.This highly-readable text provides grounds on how to plan and conduct animal experiments that can be reproduced by others. The book touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process. .  . The book addresses advanced undergraduates, graduate students and all scientists working with animals..
出版日期Book 2021
关键词experimental design; laboratory animals; veterinary genetics; registration of animal experiments; precli
版次1
doihttps://doi.org/10.1007/978-3-030-66147-2
isbn_softcover978-3-030-66149-6
isbn_ebook978-3-030-66147-2Series ISSN 2730-7859 Series E-ISSN 2730-7867
issn_series 2730-7859
copyrightSpringer Nature Switzerland AG 2021
The information of publication is updating

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书目名称Experimental Design and Reproducibility in Preclinical Animal Studies 被引频次学科排名




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Microbiology and Microbiomecrobiota. The animal host contains approximately 20,000 genes, while the microbiota contains more than 1 million genes. Therefore, many of the competences of a laboratory animal have arisen from the microbiota rather than the mammal genome. As there is substantial variation in composition between an
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Effects of Untreated Pain, Anesthesia, and Analgesia in Animal Experimentationory nervous system’s response to (potentially) harmful stimuli, but has been defined as a “subjective, sensory and emotional experience” [1, 2] in humans. It is very likely that pain, as an affective experience, also exists in other vertebrate animals than humans. Therefore, anesthesia and pain trea
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Why Do We Need a Statistical Experiment Design? stage where human trials can begin. We have to strike a harm/benefit balance, and these are now enshrined in the 3R’s principles of the European directive 2010/63/EU which is enacted in the laws of European countries. Good experimental design which will allow us to achieve this is therefore not onl
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Scholarly Publishing and Scientific Reproducibilityes. Improved author compliance to a journal’s submission guidelines, rigorous editorial vigilance by competent reviewers and journal editors, and revamped research practices and policies by research institutes can raise the reporting quality of submitted manuscripts. In this chapter, we describe the
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Defined Mutants in Higher Plants for example, states that “member states shall ensure that, unless it is inappropriate, procedures are carried out under general or local anesthesia, and that analgesia or another appropriate method is used to ensure that pain, suffering and distress are kept to a minimum.”
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