| 书目名称 | Exosomes and MicroRNAs in Biomedical Science | | 编辑 | Hamed Mirzaei,Neda Rahimian,Michael R. Hamblin | | 视频video | | | 丛书名称 | Synthesis Lectures on Biomedical Engineering | | 图书封面 |  | | 描述 | MicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19–25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner. Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typical of tumor cells, and has been associated with tumor progression and poor prognosis. Many miRNAs are up-regulated in cancer, where they can silence tumor suppressor genes such as apoptosis and immune response associated genes. Therefore, it is possible to profile the expression levels of miRNAs as biomarkers, in order to diagnose cancer and noncancerous diseases. Moreover, cancer detection in the early stages is crucial in clinical situations. Characterization of miRNAs in serum, plasma, and othe | | 出版日期 | Book 2022 | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-031-79177-2 | | isbn_softcover | 978-3-031-79172-7 | | isbn_ebook | 978-3-031-79177-2Series ISSN 1930-0328 Series E-ISSN 1930-0336 | | issn_series | 1930-0328 | | copyright | Springer Nature Switzerland AG 2022 |
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发表于 2025-3-21 18:53:32
