Titlebook: Excitatory Amino Acids and Neuronal Plasticity; Yehezkel Ben-Ari Book 1990 The Editor(s) (if applicable) and The Author(s), under exclusiv

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为敌

The Glycine Coagonist Site of the NMDA Receptorted in receptor-channel mechanisms. It also offers a new target site in drug development for the treatment of neuropa-thologies associated with NMDA receptor activation. The list of neural dysfunctions mediated in part by. synaptic activation of NMDA receptors very likely includes epileptiform seizu

fibroblast

The PCP Site of the NMDA Receptor Complexetamine selectively block responses evoked by applications of NMDA agonists while sparing those mediated by other subtypes of excitatory amino acid receptors. Since that time others including ourselves demonstrated, using patch and voltage-clamp techniques, that this blockade is both dependent upon

可忽略

Antagonists of NMDA-Activated Current in Cortical Neurons: Competition with Glycine and Blockade of ral nervous system (Mayer and Westbrook, 1987) Nearly 30 years ago, glutamate was found to depolarize neurons in most areas of the brain and spinal cord (Hayashi, 1954; Curtis et al. 1960; Krnjevic and Phillis, 1963) but it was not until pharmacological experiments revealed the presence of several d

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Experiments with Kainate and Quisqualate Agonists and Antagonists in Relation to the Sub-Classificatceptors was originally based on the selective depressant action of L-glutamic acid diethyl ester (GDEE) on quisqualate induced responses in ionophoretic experiments . (McLennan and Lodge, 1979; Watkins and Evans, 1981). This concept was supported by the opposite selectivity shown by other antagonist

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安定

gospel

Intracellular Messengers Associated with Excitatory Amino Acid (EAA) Receptors the fast excitatory neurotransmission, these amino acids appear to play crucial roles in neuronal plasticity. These include changes in neuronal development (Barnes, 1986; Balàzs et al., 1988; Didier et al., 1989), as well as changes in synaptic efficacy, which probably underlie learning and memory

预示

The Glycine Site on the NMDA Receptor: Pharmacology and Involvement in NMDA Receptor-Mediated Neurodal nervous system (CNS) are mediated by distinct receptor sub-types. Amongst these, the N-methyl-D-aspartate (NMDA) receptor has been characterized most fully in terms of its pharmacological and biophysical properties (Watkins and Evans, 1981; Mayer and Westbrook, 1987). The NMDA receptor can be div