Titlebook: Evolution-adjusted Tumor Pathophysiology:; The Novel Language o Albrecht Reichle Book 2013 Springer Science+Business Media Dordrecht 2013 B

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Targeting the Proangiogenic Network in Angiosarcomas: Biomodulatory Therapy therapy consisting of metronomic low-dose chemotherapy (trofosfamide), PPAR δ-blockage (rofecoxib) and the transcription modulator pioglitazone. Among these, one continuous complete remission (> 5 years), four complete remissions, two partial remissions, three cases of stable disease and three case

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Long-Term Results of Combined Modularized, Immune-Modulatory, Angiostatic, and Antiinflammatory There been limited. Acknowledging the fact that the continuous production of pro-inflammatory cytokines contributes to the resistance to commonly used agents, we hypothesized that a multi-targeted approach consisting of continuously administered anti-angiogenic, anti-inflammatory, immune-modulatory, and

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Redirecting and Modulating Rationalizations of Tumor-Immanent Normative Functions in Castration-Resiited. In a multicenter phase II trial, 65 patients with histologically confirmed CRPC continuously received a biomodulatory regimen during the 6-month core period for redirecting tumor-promoting normative notions, i.e. angiogenesis, inflammation, immune response and the osteoplastic process. Treatme

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Non-Hierarchically Organized Operations in Malignancies: Stromal Dysfunction Induces and Maintains Hlar components of the niche support hematopoiesis by maintaining hematopoietic stem cells (HSC) in a quiescent state but also provide growth signals in response to extrinsic hematopoietic stress. According to the cancer stem cell (CSC) hypothesis, leukemogenesis is a hierarchical process induced by

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Biomodulatory Therapy Approaches in Renal Clear Cell Carcinoma: A Perspectiveodulatory activity of VEGFR-tyrosine kinase inhibitors and transcriptional modulators (pioglitazone and interferon-alpha). Biomodulation remodels tumor-immanent normative notions by therapeutically implementing non-normative boundary conditions in such a way that tumor control becomes possible. Norm

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Proteome Analysis Identified the PPARγ Ligand 15d-PGJ2 as a Novel Drug Inhibiting Melanoma Progressi, evidence is growing that PPARγ ligands have inhibitory effects on tumor growth..To shed light on the potential therapeutic effects on melanoma we tested a panel of PPAR agonists on their ability to block tumor proliferation .. Whereas ciglitazone, troglitazone and WY14643 showed moderate effects o

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The Tumor’s Normativity: Normative Structures, Action Norms and Decision Maxims as Therapeutic Targeubs, nodes) physically rationalized, functionally established, and even protected? The inseparable relation between rationalization processes and normative notions may be shown at three observational levels. (1) For many reasons, normative notions do not constitute a posteriori classifying phrases o

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Criticizable Claims for the Validity of Communication Acts in Biological Systems: Therapeutic Implicg the context-dependent validity of communicatively integrated systems objects (molecules, pathways, cells etc.). Validity claims of experimentally defined references in terms of systems objects seem to be routinely transferable into arbitrary evolving systems. This transfer is irrespective of the s

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Evolution Theory: Its Practical Relevance for Understanding Tumor Development and Specifying Tumor T. can be suggested, if an innovative achievement may be denoted for a complex ‘learning process’. Because such models admit a clear normative reference and action-theoretical interpretation; they may be used for narrative presentations. Three main factors emerged as starting point for ., an unmet me