| 书目名称 | Evolution, Biodiversity and a Reassessment of the Hygiene Hypothesis | | 编辑 | Graham A. W. Rook,Christopher A. Lowry | | 视频video | | | 概述 | Explains why we evolved a need for exposure to the microbiota of our mothers and of the natural environment.Summarises the physiological roles of these microbial exposures, and what goes wrong when th | | 丛书名称 | Progress in Inflammation Research | | 图书封面 |  | | 描述 | .This edited collection of 12 chapters by research workers from a wide range of disciplines resolves the confusion that currently surrounds the “hygiene hypothesis” by considering the human need for exposure to microorganisms from an evolutionary point of view. The book explains why we evolved a requirement for exposure to microbiota from our mothers, from other people, and from the natural environment. It also explains the physiological roles of these exposures, what goes wrong when the exposures are distorted and how human lifestyles and activities, including degradation of the natural environment, are leading to this distortion. Particular attention is given to the range of pathologies associated with inappropriate microbial exposures and inappropriate colonization, including immunoregulatory problems such as allergies and autoimmunity, metabolic problems such as obesity and diabetes, and problems of central nervous system function and neurodegeneration. This book is of profound relevance to most medical disciplines, but also to those concerned with preserving the natural environment and with developing healthier urbanisation.. | | 出版日期 | Book 2022 | | 关键词 | hygiene hypothesis; microbiota; natural environment; biodiversity; Old Friends Hypothesis; immunoregulati | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-91051-8 | | isbn_softcover | 978-3-030-91053-2 | | isbn_ebook | 978-3-030-91051-8Series ISSN 1422-7746 Series E-ISSN 2296-4525 | | issn_series | 1422-7746 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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发表于 2025-3-21 16:53:39
