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Titlebook: Estrogens, Progestins, and Their Antagonists; Functions and Mechan Edward J. Pavlik Book 1997 Springer Science+Business Media New York 1997

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书目名称Estrogens, Progestins, and Their Antagonists
副标题Functions and Mechan
编辑Edward J. Pavlik
视频video
丛书名称Hormones in Health and Disease
图书封面Titlebook: Estrogens, Progestins, and Their Antagonists; Functions and Mechan Edward J. Pavlik Book 1997 Springer Science+Business Media New York 1997
描述These two volumes on Estrogens, Progestins, and Their Antagonists repre­ sent a thematic extension of the series, Hormones in Health and Disease. The first publication in the series, Steroid Hormone Receptors: Basic and Clinical Aspects, focused on recent advances in the anatomy of steroid receptors and members of the steroid receptor superfamily. Consistent with the spirit of the series, the authors addressed issues of clinical significance of steroid receptor detection in hormone-related disorders. The second volume in the series, Hormones and Cancer, attempted a more direct examination of ac­ tions of hormones in cancerous tissues and cells. In these two volumes, which together form the third in the series, the editor, Dr. Edward Pavlik, has introduced a team of leading investigators engaged in research on various aspects of the steroids that regulate female reproductive physiology. Estrogens and progestins, the main components of the most widely used contraceptive pills, have found a variety of uses in clinical endocrinology. These volumes contain discussions that range from the introduction of novel hormonal ligands to "hormonal antagonism by steroid analogs. A balanced treatm
出版日期Book 1997
关键词anatomy; biology; cancer; endocrinology; estrogens; genes; hormones; molecular biology; physiology; progester
版次1
doihttps://doi.org/10.1007/978-1-4612-2004-6
isbn_softcover978-1-4612-7377-6
isbn_ebook978-1-4612-2004-6
copyrightSpringer Science+Business Media New York 1997
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As a Model System to Study Steroid Hormone Receptorss, 1988). The cloning of the cDNAs for these receptors — ER in 1986 (Green et al, 1986) and hPR in 1987 (Misrahi et al, 1987) — and their subsequent expression in heterologous cell types permitted the reconstitution of hormone-responsive transcription systems that have been amenable to genetic analy
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New Models and Insights in Steroid Hormone Actionroid hormone action and identify new research areas that may increase our understanding of steroid hormone regulation. Recently, with available immunological and molecular tools, extensive research has focused on the structural aspects of steroid receptors, as well as on the interaction of receptors
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A Role for Progesterone in Multidrug Resistancemainstays of treatment is chemotherapy. However, a major problem in the treatment of most malignancies is the development of resistance to chemotherapeutic agents. Initially, many believed that the mechanisms of resistance to cancer chemotherapeutic agents were similar to those described for antibio
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Facilitated Binding of Steroid Hormone Receptors to Target DNA by the Chromatin High-Mobility Group rowth and progression of a high proportion of breast cancers,. are mediated by specific receptors. that are members of the nuclear receptor gene family. In addition to receptors for the sex steroid hormones and glucocorticoids, the gene family also includes receptors for thyroid hormone (TR), vitami
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