| 书目名称 | Estrogen Receptor and Breast Cancer |
| 副标题 | Celebrating the 60th |
| 编辑 | Xiaoting Zhang |
| 视频video | |
| 概述 | Written by World Renowned Leaders of the Estrogen Receptor and Breast Cancer Field to Celebrate the 60th Anniversary of the Discovery of Estrogen Receptor.Provides Comprehensive and Most Up-to-Date In |
| 丛书名称 | Cancer Drug Discovery and Development |
| 图书封面 |  |
| 描述 | .The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insig |
| 出版日期 | Book 2019 |
| 关键词 | estrogen receptor; breast cancer; targeted therapies against ER pathways; Tamoxifen; molecular functions |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-99350-8 |
| isbn_softcover | 978-3-030-07593-4 |
| isbn_ebook | 978-3-319-99350-8Series ISSN 2196-9906 Series E-ISSN 2196-9914 |
| issn_series | 2196-9906 |
| copyright | Springer Nature Switzerland AG 2019 |
发表于 2025-3-21 16:44:12
