Titlebook: Essential Hypertension 2; Kyuzo Aoki Book 1989 Springer Japan 1989 hypertension

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Discovery and Development of the Spontaneously Hypertensive Rathe selective inbreeding method developed hypertension without any special manipulation or experimental maneuvers. The fact that the SHR strain was obtained by only three repetitive selective inbreeding suggests that there are a few major hypertension genes and the genes are the primary cause of the blood pressure elevation in SHR.

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Role of Second Messengers on Mobilization of Calcium and Related Events in Vascular Smooth MusclesFurthermore, the Na-Ca exchange diffusion mechanism is thought to contribute partly to the reduction in the free Ca. In this chapter, the role of second messengers such as cyclic AMP, cyclic GMP, diacylglycerol (including the action of phorbol esters) and inositol 1, 4, 5-trisphosphate on Ca regulation in vascular smooth muscles is reviewed.

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Discovery and Development of the Spontaneously Hypertensive Ratscovered among ten Wistar rats supplied from the Animal Center of Kyoto University. It was thought that the hypertension may be of genetic orign. In order to prove this hypothesis I began breeding the hypertensive male rat with a normotensive female rat to obtain genetically hypertensive rats. Many

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Three-Way Classification of Hypertension: Gene Hypertension, Environment Hypertension, and Disease Harch of renal hypertension. In 1872, Gull and Sutton [2] demonstrated arterio-capillary fibrosis in patients with hypertension and separated the hypertensive disease from kidney disease. Frank designated in 1911 [3] this hypertensive disease as “.”, which has been translated into English as essentia

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Membrane Potential and Calcium Channels in Arterial Smooth Muscle Cellsbit mesenteric arteries by a common mechanism, namely by opening voltage-dependent calcium channels. The effects of noradrenaline and membrane depolarization on calcium channels were examined directly at the single channel level using the patch clamp technique. Membrane depolarization increased calc