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Titlebook: Epstein-Barr Virus and Human Disease • 1988; Dharam V. Ablashi,Alberto Faggioni,Gary R. Pearson Book 1989 The Humana Press Inc. 1989 DNA.P

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Characterization of a cDNA of Epstein-Barr Virus DNase Geneay result in 7 amino acid residue changes.. The products of in vitro transcription and translation of a subclone, pGEM3–BG9, appeared to contain EBV DNase activity and a 52 kd protein was immunoprecipitated with a NPC patient’s serum containing high level of antibody to this enzyme activity.
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The 5’Flanking Region of the Gene for EBNA2 Contains a Cell Type Specific ,-Acting Regulatory Elemenmilar to the “negative noodles” often found in activators of transcription. Thus, EBNA2 presumably has its primary action at the level of transcription and might regulate the expression of an assortment of cellular and/or viral genes.
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