| 书目名称 | Epigenomics | | 编辑 | Anne C. Ferguson-Smith,John M. Greally,Robert A. M | | 视频video | | | 概述 | Epigenomics tells us how the genome works.Characterising the epigenome is the next big step after determining the sequence of the genome.Epigenetic influences are major causes of disease.The epigenome | | 图书封面 |  | | 描述 | .Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in health and in disease. Relationships are emerging between the underlying DNA sequence and dynamic epigenetic states and their consequences,such as the role of RNA interference and non-coding RNA. These integrated approaches go hand-in-hand with studies describing the genomic locations of epigenetic modifications in different cell types at different times...The excitement and curiosity surrounding epigenomics is driven by a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. Research has shown that the adaptability and vu | | 出版日期 | Book 2009 | | 关键词 | Chromosom; DNA; Epigenetic modifications; genes; genetics; translation | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4020-9187-2 | | isbn_softcover | 978-94-007-8954-8 | | isbn_ebook | 978-1-4020-9187-2 | | copyright | Springer Science+Business Media B.V. 2009 |
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发表于 2025-3-21 18:03:42
