Titlebook: Epigenetics in Cardiac Disease; Johannes Backs,Timothy A. McKinsey Book 2016 Springer International Publishing Switzerland 2016 Cardiac de

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BET Bromodomains and P-TEFb in Cardiac Transcription and Heart Failure Pathogenesis,art and their role in pathologic cardiac plasticity and HF pathogenesis. We will highlight recently published studies that implicate BET family bromodomain-containing coactivator proteins as a critical link between activated cardiac enhancers, P-TEFb (positive transcription elongation factor b), and

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2509-7830 ally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics..978-3-319-82360-7978-3-319-41457-7Series ISSN 2509-7830 Series E-ISSN 2509-7849

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Automobile Performance and Kustom Kulture,ations can be recognized by specialized “reader” proteins which modulate cardiomyocyte function. Future studies will be important to unravel the complex interplay between epigenetic modifications of DNA and histones and to identify the involved signaling pathways.

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The Iconography of the American RevolutionA-modifying enzymes to control chromatin structure and reprogram gene expression in pathologically stressed hearts. More recently, a chromatin-remodeling factor was found to interact with a cardiac-specific long noncoding RNA to control gene expression and maintain cardiac homeostasis. These functio

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https://doi.org/10.1057/9781137374264art and their role in pathologic cardiac plasticity and HF pathogenesis. We will highlight recently published studies that implicate BET family bromodomain-containing coactivator proteins as a critical link between activated cardiac enhancers, P-TEFb (positive transcription elongation factor b), and

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https://doi.org/10.1057/9780230623309s and functional consequences of DNA methylation. Its potential role in heart disease and its link to other epigenetic processes are examined and summarized, and opposing results from major studies in the field are discussed. The chapter concludes with an outlook on the field, including possible therapeutic and diagnostic applications.

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