Titlebook: Epigenetics in Allergy and Autoimmunity; Christopher Chang,Qianjin Lu Book 2020 Springer Nature Singapore Pte Ltd. 2020 Epigenetics.Allerg

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https://doi.org/10.1057/9780230606920he importance of dysregulated epigenetic modifications in immune cells in pathogenesis of lupus, and has identified epigenetic changes as potential biomarkers and therapeutic targets. Environmental factors, such as drugs, diet, and pollution, may also be the triggers of epigenetic changes. Therefore

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Pier Francesco Asso,Luca Fiorito setting to restore normal epigenetic patterns (Generali et al. in J Autoimmun 83:51–61, .), providing novel therapeutic potential as novel treatment targets for psoriasis. Indeed, medications previously used to treat autoimmune diseases have later been discovered to exert their action via epigeneti

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American Presidential Statecrafte closely correlated with disease severity. In this chapter, we not only review new advancements on the epigenetic mechanisms involved in the pathogenesis of SSc and potential epigenetic biomarkers, but also discuss the therapeutic potential of epigenetic targeting therapeutics such as DNA methylati

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The Development of Epigenetics in the Study of Disease Pathogenesisnetic biomarkers. We conclude by offering two examples of modern state-of-the-art integrated multi-omics studies of epigenetics in disease pathogenesis, one which sought to capture shared mechanisms among multiple diseases, and another which used epigenetic big data to better understand the pathogen

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The Role of Genetics, the Environment, and Epigenetics in Atopic Dermatitision between the relationship of an impaired skin barrier and immune and environmental factors, such as tobacco exposure, pollutants, microbes, and diet and nutrients. AD is a multigene disease, and thus there are many targets for regulation of expression of these genes which may contribute to the pa